N-BUTYL 4-AMINOBENZOATE
n-butyl p-aminobenzoate
CAS: 94-25-7
Molecular Formula: C11H15NO2
N-BUTYL 4-AMINOBENZOATE - Names and Identifiers
| Name | n-butyl p-aminobenzoate |
| Synonyms | butesin Butamben PLANOFORM Scuroforme BUTYL-P-AMINOBENZOATE Butyl,4-Aminobenzoate Butyl 4-aminobenzoate Butyl 4-aminobenzoato N-BUTYL 4-AMINOBENZOATE N-BUTYL P-AMINOBENZOATE n-butyl p-aminobenzoate butyl para-aminobenzoate 4-(Butoxycarbonyl)aniline 4-amino-benzoicacibutylester p-aminobenzoic acid butyl ester P-AMINOBENZOIC ACID BUTYL ESTER Butyl 4-Aminobenzoate (Butamben) 4-AMINOBENZOIC ACID N-BUTYL ESTER |
| CAS | 94-25-7 |
| EINECS | 202-317-1 |
| InChI | InChI=1/C11H15NO2/c1-2-3-8-14-11(13)9-4-6-10(12)7-5-9/h4-7H,2-3,8,12H2,1H3 |
N-BUTYL 4-AMINOBENZOATE - Physico-chemical Properties
| Molecular Formula | C11H15NO2 |
| Molar Mass | 193.24 |
| Density | 1.0945 (rough estimate) |
| Melting Point | 57-58°C(lit.) |
| Boling Point | 174°C8mm Hg(lit.) |
| Flash Point | 184.6°C |
| Water Solubility | Very slightly soluble in water. |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.000227mmHg at 25°C |
| Appearance | White crystal |
| Color | White |
| Merck | 14,1512 |
| BRN | 1211465 |
| pKa | pKa 5.38 (Uncertain) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Sensitive | Light Sensitive |
| Refractive Index | 1.5480 (estimate) |
| MDL | MFCD00017112 |
| Physical and Chemical Properties | White crystalline powder. Melting point 57-59 ℃, boiling point 174 ℃(1.06kPa) soluble in dilute acid, alcohol, chloroform, ether and fatty oil, almost insoluble in water. Boiling with water can slowly decompose. |
| Use | Mainly used for ultraviolet absorption of cosmetics |
| In vitro study | Butamben (500 μM) blocks 90% of the control barium current, and this level is reached within 4 min in PC12 cells. Butamben (100 μM; 2-10 min) increases the inactivation of the fast Na + channels, but not of the slow Na + channels. |
| In vivo study | Butamben (0.5-50 mM; the distal portion of the tail was immersed for 2 min) has an S-shape dose-dependent analgesic activity in the radiant heat tail-flick assay of mice. |
N-BUTYL 4-AMINOBENZOATE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitization by skin contact |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | DG1530000 |
| TSCA | Yes |
| HS Code | 29224995 |
N-BUTYL 4-AMINOBENZOATE - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | bustamen (Butyl 4-aminobenzonate) is a long-acting local anesthetic used in the treatment of chronic pain. |
| Target | Calcium Channel Sodium Channel |
| Use | organic synthesis intermediates. mainly used for ultraviolet absorption in cosmetics |
| production method | p-aminobenzoic acid and n-butanol were heated under reflux for 6h in the presence of concentrated sulfuric acid. After completion of the reaction, water was added for vapor distillation to recover n-butanol. The distillate was cooled, and the crude product of n-butyl p-aminobenzoate sulfate was precipitated. The crude product was dissolved in hot water, neutralized with concentrated ammonia water, and n-butyl p-aminobenzoate was precipitated. The yield was 70-72%. |
| category | flammable solid |
| toxicity grade | high toxicity |
| Acute toxicity | intraperitoneal-mouse LD50: 67 mg/kg |
| flammability hazard characteristics | |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| extinguishing agent | water, dry powder, dry sand, carbon dioxide, foam, 1211 extinguishing agent |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:21:28
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